May 24, 2022

Job Description

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Disease Area x (DAx) department is accommodated within NIBR and is a group of about 145 scientists that work in close collaboration with colleagues from Novartis Research and Development on several therapeutic areas with high unmet need, including kidney disease. Using a diverse array of approaches and cutting-edge technology, DAx aims to develop drugs that improve the lives of individuals suffering from chronic kidney diseases for which there is currently no cure.

Impact of this position
We are seeking an innovative, independent and dynamic renal research scientist with broad expertise in molecular and cellular biology to join a discovery biology team focused on developing innovative therapeutic agents in the area of polycystic kidney disease (PKD).

Your key responsibilities
Your responsibilities will include, but not limited to:

• Contribute to the NIBR drug discovery process with the goal to discover and develop novel therapeutic treatment options for patients with PKD.
• Conduct impactful research in the area of PKD and provide scientific leadership and innovation by acting as subject matter expert on genetic cystic kidney diseases.
• Lead early drug projects in the renal disease space, propose and champion new targets and novel approaches for disease treatment. Act as a leader of a team tasked with the triage and validation of new biology knowledge harnessed from genome wide and pharmacological screens in complex 3D human model systems.
• Design and execute in vitro and in vivo experimental research plans to evaluate targets modulating renal cyst expansion, inflammation and fibrosis.
• Develop assays and implement new technologies to enable the delivery of high quality data-driven package and enable project decisions a/o portfolio transitions. Record and interpret experimental data, and present results to project team members.
• Engage in interdisciplinary research requiring the application of specialized scientific knowledge and advanced laboratory techniques, in particular engineered complex cellular models and their use with chemical biology and gene editing approaches.
• Collaborate with other scientists in a global matrixed dynamic environment fostering innovation and advance project activities. Develop and maintain external relationships/contacts.
• Deliver impact to projects by identifying technical trends, both internal and external to your discipline.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

Minimum requirements
What you will bring to the role:

• A PhD and/or MD degree with postdoctoral experience and a minimum of three years of research in renal biology and physiology, preferably in the pharmaceutical / biotechnology industry or academia.
• In-depth knowledge of (patho-)physiology of PKD, including direct experience with PKD mechanisms and complex in vitro renal cell-based platforms recapitulating human cystic phenotype and in vivo models of disease progression.
• Extensive “hands-on” experience and proven track-record in the use of a wide range of cellular, biochemical and genome editing methods and technologies to unravel complex cellular signaling pathways
• Familiarity with “state of the art” computational and analytical approaches and be comfortable with analyzing large scale datasets
• A track record of leading drug discovery projects and working alongside disease areas specialists to bring mechanistic target biology and target validation understanding for renal diseases.
• Strong communication skills with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally
• A proven scientific impact on innovation through a solid publication track record and strong external scientific network with academic experts.
• Excellent oral and written communication skills (in English) are essential

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.


Why consider Novartis?
799 million. That’s how many lives our products touch. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Cambridge, MA
Research & Development
Full Time
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Research Investigator, Drug Discovery – Polycystic Kidney Diseases

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