Jelena Curcic, PhD, Translational Medicine, Basel, Switzerland

Translational Medicine – Digital Biomarkers

Basel, Switzerland

Technology is changing the way we think about drug treatment efficacy and the practice of medicine. Sensor technologies are rapidly evolving to measure more and more body functions and many aspects of patient’s daily life. Sensors produce vast amounts of data and we leverage advanced analytics to gain transformative endpoints for our clinical trials. These novel digital endpoints have begun to clarify health benefits in ways that previously were unmeasurable.

Clinical research at NIBR represents the early evaluation of drugs in humans with and without disease in established or new indications. As such, the inclusion of digital endpoints in NIBR studies aims to deepen and broaden our understanding of patient burden, disease progression, and treatment response, in the earliest stages of the Novartis clinical drug development process.

Our group in NIBR is dedicated to develop those new digital endpoints by combining emerging technologies and advanced analytics. We are unleashing the power of data and technology to help patients, lower the burden of study participants, create clinically meaningful and sensitive outcomes and advance our medicines.

Selected Publications

The Causes of Gastroesophageal Reflux after Laparoscopic Sleeve Gastrectomy: Quantitative Assessment of the Structure and Function of the Esophagogastric Junction by Magnetic Resonance Imaging and High-Resolution Manometry.
Quero G, Fiorillo C, Dallemagne B, Mascagni P, Curcic J, Fox M, Perretta S.
Obes Surg. 2020 Jun;30(6):2108-2117

What to eat and drink in the festive season: a pan-European, observational, cross-sectional study.
Parker HL, Curcic J, Heinrich H, Sauter M, Hollenstein M, Schwizer W, Savarino E, Fox M.
Eur J Gastroenterol Hepatol. 2017 May;29(5):608-614

Abnormal structure and function of the esophagogastric junction and proximal stomach in gastroesophageal reflux disease.
Curcic J, Roy S, Schwizer A, Kaufman E, Forras-Kaufman Z, Menne D, Hebbard GS, Treier R, Boesiger P, Steingoetter A, Fried M, Schwizer W, Pal A, Fox M.
Am J Gastroenterol. 2014 May;109(5):658-67

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