393791BR
Mar 07, 2024
USA
About the Role
Internal Job Title: Discovery Postdoctoral Fellow
Position Location: Cambridge, MA onsite
About the role:
We are seeking a highly motivated and skilled candidate to join Novartis Biomedical Research as a Discovery Postdoctoral Fellow within the Discovery Sciences (DSc) department to work on expanding the scope of covalent drug discovery.
We invite applications for a Discovery Postdoctoral Fellow to join our dynamic Exploratory Chemical Biology (ECB) research team in Cambridge, MA. The role presents opportunities to work collaboratively across scientific and organizational boundaries to develop novel technologies and targeted assays focused around discovering and characterizing novel covalent small molecule-protein interactions for specific targets with the aim of identifying chemical starting points for targeted covalent inhibitor development or tool compounds to further enable screening campaigns. The ideal candidate will be an ambitious researcher eager to expand their knowledge and skills while contributing and pushing the boundaries of covalent drug discovery.
Discovery Fellows have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. Novartis Biomedical Research is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. You will join our postdoctoral community for dedicated events, including the monthly postdoctoral seminars and our annual Research Day Symposium. All Fellows participate to our robust curriculum designed to develop scientific and professional skills. The postdoctoral term is up to 4 years.
Key responsibilities:
As a Discovery Fellow, you will:
• Innovate with the development of high throughput assays (nanoBRET, ELISA, TR-FRET, HTRF, etc.) for targeted covalent drug discovery in native cellular environments.
• Facilitate profiling the interactome of diverse chemical matter with various targeted mass spectrometry technologies (parallel reaction monitoring), as well as orthogonal unbiased chemical proteomic workflows (affinity, photoaffinity, covalent, CETSA, ABPP, etc.).
• Validate and characterize roles of newly discovered small molecule-protein pair interactions.
• Actively work independently as well as collaboratively with interdisciplinary teams with a diverse set of backgrounds. and expertise within the DSc and ECB ecosystems.
• Communicating project progress proactively and transparently.
Position Location: Cambridge, MA onsite
About the role:
We are seeking a highly motivated and skilled candidate to join Novartis Biomedical Research as a Discovery Postdoctoral Fellow within the Discovery Sciences (DSc) department to work on expanding the scope of covalent drug discovery.
We invite applications for a Discovery Postdoctoral Fellow to join our dynamic Exploratory Chemical Biology (ECB) research team in Cambridge, MA. The role presents opportunities to work collaboratively across scientific and organizational boundaries to develop novel technologies and targeted assays focused around discovering and characterizing novel covalent small molecule-protein interactions for specific targets with the aim of identifying chemical starting points for targeted covalent inhibitor development or tool compounds to further enable screening campaigns. The ideal candidate will be an ambitious researcher eager to expand their knowledge and skills while contributing and pushing the boundaries of covalent drug discovery.
Discovery Fellows have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. Novartis Biomedical Research is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. You will join our postdoctoral community for dedicated events, including the monthly postdoctoral seminars and our annual Research Day Symposium. All Fellows participate to our robust curriculum designed to develop scientific and professional skills. The postdoctoral term is up to 4 years.
Key responsibilities:
As a Discovery Fellow, you will:
• Innovate with the development of high throughput assays (nanoBRET, ELISA, TR-FRET, HTRF, etc.) for targeted covalent drug discovery in native cellular environments.
• Facilitate profiling the interactome of diverse chemical matter with various targeted mass spectrometry technologies (parallel reaction monitoring), as well as orthogonal unbiased chemical proteomic workflows (affinity, photoaffinity, covalent, CETSA, ABPP, etc.).
• Validate and characterize roles of newly discovered small molecule-protein pair interactions.
• Actively work independently as well as collaboratively with interdisciplinary teams with a diverse set of backgrounds. and expertise within the DSc and ECB ecosystems.
• Communicating project progress proactively and transparently.
Diversity & Inclusion / EEO
We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:
Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:
- Novartis: e-mail [email protected] or call +1 (877)395-2339
- Sandoz: e-mail [email protected] or call: +1-609-422-4098
Role Requirements
Role Requirements:
• PhD in chemical biology, biochemistry, molecular or cellular biology, or related field.
• Proficiency with immunoassay and proximity-based assay development (ex. ELISA, HTRF, TR-FRET, and nanoBRET assays) as well as chemical proteomic workflows.
• Experience with mammalian cell culture and molecular and cell biology techniques.
• Excellent problem-solving skills and ability to troubleshoot technical issues.
• Strong publication record or other scientific achievements (i.e. awards, patents, grants).
• Stellar analytical, communication, presentation, and organizational skills.
• Passion for fundamental exploratory research and boundless curiosity.
• PhD students in the last year of their thesis work are eligible to apply.
How to apply:
Please submit your CV and cover letter by April 1 for consideration.
Please make sure to discuss in the cover letter how this training program will help you fulfill your career goals. For more information about our postdoctoral program, please visit: https://www.novartis.com/careers/postdoc-program
The pay rate for this position at commencement of employment is expected to be $75,000 per year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. #pdx #LI
Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards
Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
• PhD in chemical biology, biochemistry, molecular or cellular biology, or related field.
• Proficiency with immunoassay and proximity-based assay development (ex. ELISA, HTRF, TR-FRET, and nanoBRET assays) as well as chemical proteomic workflows.
• Experience with mammalian cell culture and molecular and cell biology techniques.
• Excellent problem-solving skills and ability to troubleshoot technical issues.
• Strong publication record or other scientific achievements (i.e. awards, patents, grants).
• Stellar analytical, communication, presentation, and organizational skills.
• Passion for fundamental exploratory research and boundless curiosity.
• PhD students in the last year of their thesis work are eligible to apply.
How to apply:
Please submit your CV and cover letter by April 1 for consideration.
Please make sure to discuss in the cover letter how this training program will help you fulfill your career goals. For more information about our postdoctoral program, please visit: https://www.novartis.com/careers/postdoc-program
The pay rate for this position at commencement of employment is expected to be $75,000 per year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. #pdx #LI
Why Novartis? Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards
Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Biomedical Research
DSc
USA
Cambridge, MA
NIBRI
Research & Development
Full Time
Regular
No
