Bioengineer, Renal Translational Research, Principal Scientist II

Join Novartis as a Renal Bioengineer and contribute to groundbreaking translational research in renal health. As a Principal Scientist II at our Cambridge, USA campus, you’ll be at the forefront of innovation, leveraging cutting-edge technology to transform patient care in nephrology. Be part of a team where your expertise in bioengineering shapes the future of renal medicine.

The Bioengineer will bring key professional experiences to Translational Research and Data Sciences in Disease Area Exploratory to contribute to drug discovery and development for renal diseases. This role involves fostering collaboration and alignment in a matrix environment to enable the science, people, and strategy. The successful candidate will work at the cutting edge to advance the discovery and understanding of transformative medicines and biomarkers for patients with podocytopathies and polycystic kidney diseases. 

In this role, you will develop, execute, and deliver on complex micro physiological ex vivo models (precision cut region-specific kidney slices) to interrogate the effects of variable micro-environments on key renal-resident regional cells (glomerular, tubular).

Key Responsibilities :

• Lead the development of translationally relevant (human and murine) scalable bioreactor-based complex tissue models (e.g., precision cut region specific kidney slices) including smart biomaterials and microfluidics to monitor tissue viability and cell function.

• Interrogate the mechanobiology and molecular mechanisms underlying the effect of biophysical stimuli (e.g. shear stress, cyclic stretch, extracellular matrix topography/stiffness).

• Evaluate and apply these complex models for suitability and application in target and pathway identification, validation, modulation, and therapeutic intervention.

• Integrate insights from phenotypic models with high throughput omics profiling, disease biology, molecular and cellular characterization of disease, to enable drug hunting and biomarker discovery.

• Achieve high scientific, operational, and cultural standards, in alignment with biology and translational science experts within the department and in the matrix community.

• Champion alliances with academic clinical centers and/or contract research organizations, to guide the implementation of new technologies, platforms, and acquisition of disease-relevant human tissues.

Essential Requirements:

• Ph.D. with 6 years of related proven ability in industry with a track record of strong achievement, or equivalent experience.

• Champion a culture of innovative thinking, scientific excellence, and strategic execution, delivering high performance with a tactical attitude and a culture of trust (inspired, curious, unbossed).

• Collaborating across boundaries, strong networking and communication skills.

• Passionate about achieving goals while adhering to Novartis standards in quality, ethics, health and safety, environmental sustainability, and information security.

Desirable Requirements

• A resilience for prioritizing the unmet medical needs of patients.

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Novartis Compensation and Benefit Summary: While salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network