Safety and Efficacy Study of Fingolimod in Taiwanese Adults (≥ 20years) With Relapsing Remitting Multiple Sclerosis

Inclusion Criteria:

-Patients with relapsing-remitting multiple sclerosis that are fingolimod treatment naive
at the time of study entry and are newly starting fingolimod based on physician judgement
and according to Taiwan's fingolimod package insert (version TWI-090420)

Exclusion Criteria:

- Patients with the diagnosis of neuromyelitis optica.

- Patients who are being treated with any investigational drug at the time of study
entry.

- In the last 6 months experienced myocardial infarction, unstable angina, stroke,
transient ischemic attack, decompensated heart failure requiring hospitalization or
Class III/IV heart failure

- A history or presence of Mobitz Type II second-degree or third-degree
atrioventricular block or sick sinus syndrome, unless patient has a functioning
pacemaker

- A baseline QTc interval ≥ 500 msec

- Cardiac arrhythmias requiring anti-arrhythmic treatment with Class Ia or Class III
anti-arrhythmic drugs

- Patient with known immune deficiency, increased risk of opportunistic infection,
severe active infection or chronic active infection.

- Patients with severe active malignancies, except for basal cell epithelioma

- Patients with severe hepatic insufficiency

- Pregnant or nursing (lactating) women or women of childbearing potential unless on
contraception