Asciminib Roll-over Study

Key Inclusion Criteria:

1. Participant with PH+ CML or PH+ ALL currently receiving treatment with asciminib
(single agent or in combination with imatinib, nilotinib or dasatinib), imatinib,
nilotinib or bosutinib alone within a Novartis-sponsored study and, in the opinion
of the Investigator, would benefit from continued treatment.

2. Participant has demonstrated compliance on the parent study protocol and is willing
and able to comply with scheduled visits, treatment plans and any other study
procedures.

Key Exclusion Criteria:

1. Participant has been discontinued from parent study treatment.

2. Participant currently has unresolved toxicities reported as possibly related to
study treatment in the parent study.

3. Participant's ongoing treatment is currently approved and reimbursed at country
level.

4. Pregnant or nursing (lactating) women.

5. Women of child-bearing potential, unless they are using highly effective methods of
contraception and willing to continue while taking study treatment.

6. Sexually active males receiving imatinib, nilotinib, bosutinib or dasatinib
unwilling to follow the relevant contraception requirements in the local prescribing
information.

7. Applicable only for participants on bosutinib treatment that switch to asciminib
treatment at enrollment:

- Asymptomatic pancreatitis

- abnormal ECG

- any grade 3 or 4 toxicity not resolved to grade 2 or lower within 28 days
before starting asciminib treatment

Other protocol-defined Inclusion/Exclusion criteria may apply.